Abstract
In the present paper we describe the synthesis of some dermorphin and deltorphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Analgesics, Opioid / chemical synthesis*
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Analgesics, Opioid / chemistry
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Analgesics, Opioid / pharmacology
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Animals
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Glycosylation
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Guinea Pigs
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In Vitro Techniques
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Injections, Subcutaneous
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Male
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Mice
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Muscle, Smooth / drug effects
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / pharmacology
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Opioid Peptides
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Receptors, Opioid / drug effects
Substances
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Analgesics, Opioid
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Oligopeptides
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Opioid Peptides
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Receptors, Opioid
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deltorphin
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dermorphin